2-(bromomethyl)-4-chloro-1-methylbenzene synthesis
- Product Name:2-(bromomethyl)-4-chloro-1-methylbenzene
- CAS Number:869721-21-1
- Molecular formula:C8H8BrCl
- Molecular Weight:219.51
58966-29-3
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Yield:869721-21-1 98%
Reaction Conditions:
with carbon tetrabromide;triphenylphosphine in diethyl ether at 20; for 1 h;Inert atmosphere;
Steps:
10 Synthesis Example 10 Synthesis of compound (E-2)
Compound (E-1) in a 500 mL four-necked flask equipped with a stirrer under a nitrogen atmosphere7.30 g (46.6 mmol), triphenylphosphine 13.5 g (51.5 mmol) and 70 mL of diethyl ether were added, and the mixture was stirred at room temperature for 5 minutes. Add four odors to this solution.Carbon dioxide 16.2 g (48.8 mmol) dissolved in diethyl ether 20 mLThe liquid was added dropwise over 20 minutes, and the mixture was further stirred at room temperature for 1 hour. After the reaction was completed, the reaction solution was filtered... The obtained filtrate was purified by silica gel column chromatography. Further vacuum distillation to lowerThe boiling impurities were removed to obtain 10.0 g of a pale yellow oil (yield 98%, purity 98.8%).).
References:
JP5754116,2015,B2 Location in patent:Paragraph 0082; 0083-0084
7499-06-1
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58966-34-0
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615-60-1
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31684-14-7
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122488-73-7
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