Benzene, 1-(bromomethyl)-4-chloro-2-methyl- synthesis
- Product Name:Benzene, 1-(bromomethyl)-4-chloro-2-methyl-
- CAS Number:122488-73-7
- Molecular formula:C8H8BrCl
- Molecular Weight:219.51
129716-11-6
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122488-73-7
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Yield:122488-73-7 67%
Reaction Conditions:
with phosphorus tribromide in diethyl ether at 20;
Steps:
75.2
A solution containing gave (4-Chloro-2-methyl-phenyl)-methanol (2 g, 13 mmol) and PBr3 (1.3 mL, 14 mmol) in 150 mL of diethyl ether was allowed to stir at room temperature overnight. The reaction was diluted with ether and washed with water. The organic phase was dried over magnesium sulfate. Filtration, removal of solvent and purification of the residue via biotage eluting with 20% ethyl acetate/hexanes gave 1-Bromomethyl-4- chloro-2-methyl-benzene (1.89g, 67%) as a colorless oil. 1H NMR (CDCl3, 400 MHz) No. 7. 26- 7.11 (3H, m), 4.67 (2H, s), 2.39 (3H, s.)
References:
WO2005/51304,2005,A2 Location in patent:Page/Page column 121
7499-07-2
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615-60-1
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$70.00/500mg
869721-21-1
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