2'-C-Methyl-, 2',3',5'-tribenzoateuridine synthesis
- Product Name:2'-C-Methyl-, 2',3',5'-tribenzoateuridine
- CAS Number:23643-36-9
- Molecular formula:C31H26N2O9
- Molecular Weight:570.55
Yield:23643-36-9 90.3%
Reaction Conditions:
with N,O-bis-(trimethylsilyl)-acetamide;tin(IV) chloride in acetonitrile at 75;Temperature;
Steps:
1.4 Step 4, Synthesis of Compound Α4
50 g of compound A3, 1 lg of uracil, 26 g of N,0-bis(trimethylsilyl)acetamide and a second organic solvent were added to the reaction flask, and the second organic solvent was acetonitrile, N,0-double (three The mass ratio of methylsilylacetamide to compound 3 is 1:1, the temperature is raised to 75 ° C, and 45 g of tin tetrachloride is slowly added dropwise. After the reaction, water and alkali are added to neutralize, and dichloromethane is added for extraction. The phases were separated, the organic phase was concentrated, beaten, and filtered to obtain Compound A4 in a yield of 90.3%
References:
CN108440613,2018,A Location in patent:Paragraph 0022; 0025; 0054
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