2-CHLORO-1,3-DIFLUORO-5-NITRO-BENZENE synthesis
- Product Name:2-CHLORO-1,3-DIFLUORO-5-NITRO-BENZENE
- CAS Number:3828-41-9
- Molecular formula:C6H2ClF2NO2
- Molecular Weight:193.54
50408-94-1
32 suppliers
$65.00/100mg
3828-41-9
34 suppliers
$150.00/1g
Yield:3828-41-9 90%
Reaction Conditions:
with formamide in N,N-dimethyl-formamide at 60;Reagent/catalyst;Solvent;
Steps:
11 Example 11
50 g of 2,4-difluoro-3-chloronitroaniline was dissolved in 300 g of N, N-dimethylformamide,spare.74 g of t-butyl nitrite (mol of t-butyl nitrite: 2,4-difluoro-3-chloronitroaniline = 3: 1) was added to a 1000 ml dark-300 g of N, N-dimethylformamide,Heating up to 60 ,The above-mentioned standby solution was started to drop.Drip added insulation to complete reaction,Distillation under reduced pressure to get 3,5-difluoro-4-chloronitrobenzene crude,And then decompressed in addition to high-purity 3,5-difluoro-4-chloronitrobenzene (purity 99%, yield 60%).; On the basis of Example 1,To the initial 1000ml dark four bottles were added 4.9g cuprous chloride (mol than chlorinatedCuprous: 2,4-difluoro-3-chloronitroaniline = 0.25: 1),Other conditions remain unchanged,High purity 3,5-difluoro-4-chloronitrobenzene (purity 99%, yield 69%).; To the beginning of 1000ml dark four bottles of additives added 40g urea (mol than urea:2,4-difluoro-3-chloronitroaniline = 3: 1),Other conditions remain unchanged,High purity 3,5-difluoro-4-chloronitrobenzene (purity 99%, yield 78%).; On the basis of Example 3,Using different solvents instead,The low boiling solvent is recovered by atmospheric distillation,Other conditions remain unchanged.The results obtained are shown in Table 1; On the basis of Example 8,Using different additives (mol ratio unchanged) instead,The low boiling solvent is recovered by atmospheric distillation,Other conditions remain unchanged.The results obtained are shown in Table 2.
References:
CN106117067,2016,A Location in patent:Paragraph 0019; 0020; 0021; 0022; 0023; 0024; 0025-0032
60903-85-7
1 suppliers
inquiry
3828-41-9
34 suppliers
$150.00/1g
658-07-1
115 suppliers
inquiry
3828-41-9
34 suppliers
$150.00/1g
880-78-4
127 suppliers
$30.00/1g
3828-41-9
34 suppliers
$150.00/1g