2-CHLORO-1-(4-IODOPHENYL)ETHANONE synthesis
- Product Name:2-CHLORO-1-(4-IODOPHENYL)ETHANONE
- CAS Number:4209-04-5
- Molecular formula:C8H6ClIO
- Molecular Weight:280.49
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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4209-04-5
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Yield: 73%
Reaction Conditions:
with iron(III) chloride;silica gel in dichloromethane at 20; for 0.166667 h;
Steps:
General procedure for α-halomethyl ketones
General procedure: A 5mL round-bottom flask was charged with FeCl3 (0.25 mmol), silica gel (100mg) and DCM (2mL). Then a 1 mL dichloromethane solution with α-diazo-ketone (0.50 mmol) was slowly injected. After stirring for 10 mins under room temperature, the reaction mixture was concentrated in vaccuo and purified via column chromatography with 10:1 PE/EA to get the desired α-haloketone.
References:
Shi, Xinxia;Zhang, Lingqiong;Yang, Pengfei;Sun, Han;Zhang, Yilan;Xie, Chunsong;Ou-yang, Zhen;Wang, Min [Tetrahedron Letters,2018,vol. 59,# 13,p. 1200 - 1203] Location in patent:supporting information
13329-40-3
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4209-04-5
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inquiry
1000210-73-0
0 suppliers
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4209-04-5
17 suppliers
inquiry