2-Chloro-4-methylpyrimidine synthesis
- Product Name:2-Chloro-4-methylpyrimidine
- CAS Number:13036-57-2
- Molecular formula:C5H5ClN2
- Molecular Weight:128.56
5424-21-5
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13036-57-2
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$6.00/1g
Yield:13036-57-2 74.4%
Reaction Conditions:
with ammonium hydroxide;zinc for 2 h;Reflux;
Steps:
1.3 (3) Synthesis of 2-chloro-4-methyl pyrimidine
To the reaction flask were sequentially added 2,4-dichloro-6-methyl-pyrimidine (15.00 g, 92.00 mmol), zinc powder (18.05 g, 276.00 mmol), ammonia (38.70 g, 276 mmol) and stirred at to the reaction flask was added water (120 ml). The reaction was heated at reflux for 2 hours, the reaction solution was cooled to room temperature, suction filtered, the filtrate was extracted with ethyl acetate (2x200 ml), the organic layer was post-saturated brine (150 ml), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure the residue was purified by column chromatography (eluent to PE: EA = 5: 1), to give a white solid 8.8 g, yield 74.4%
References:
Shenyang Pesticide Chemical Co., Ltd.;Li, Bin;Wang, Gang;Fan, Xiaoxi;Lu, Liang;Li, Keke;Shi, Xuegeng CN105732587, 2016, A Location in patent:Paragraph 0117; 0118; 0119
3934-20-1
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676-58-4
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13036-57-2
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13036-57-2
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108-52-1
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1722-12-9
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13036-57-2
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