2-chloro-6-(methylthio)benzaldehyde synthesis
- Product Name:2-chloro-6-(methylthio)benzaldehyde
- CAS Number:201987-39-5
- Molecular formula:C8H7ClOS
- Molecular Weight:186.66
387-45-1
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$9.00/1g
5188-07-8
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$13.00/5g
201987-39-5
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$110.00/500mg
Yield:201987-39-5 56%
Reaction Conditions:
in N,N-dimethyl-formamide at 0 - 25; for 5 h;Temperature;
Steps:
4.A; 6.A Step A: Preparation of 2-chloro-6-(methylthio) benzaldehyde
To a solution of 2-chloro-6-fluorobenzaldehyde (0.5 g, 3.15 mmol) in N,N-dimehtyl formamide (8 mL), sodium methanethiolate (0.22 g, 3.15 mmol) was added at 0 °C. The reaction mixture was warmed to 25 °C and stirred over 5 h. The reaction mixture was diluted with water (10 mL) then extracted twice with ethyl acetate (35 mL). The combined ethyl acetate layer was washed with brine and evaporated under reduced pressure. The obtained crude was purified by combiflash chromatography to obtain 2-chloro-6- (methylthio)benzaldehyde (0.33 g, 1.77 mmo1, 56% yield). MS: m/z = [M+1].
References:
WO2021/94904,2021,A2 Location in patent:Page/Page column 71; 73
83-38-5
454 suppliers
$6.00/10g
5188-07-8
287 suppliers
$13.00/5g
201987-39-5
18 suppliers
$110.00/500mg
83-38-5
454 suppliers
$6.00/10g
5188-07-8
287 suppliers
$13.00/5g
918882-53-8
17 suppliers
$708.39/250mg
201987-39-5
18 suppliers
$110.00/500mg