2-CHLOROETHYL ISOBUTYL SULFIDE synthesis

3synthesis methods

Product Name:2-CHLOROETHYL ISOBUTYL SULFIDE
CAS Number:4303-44-0
Molecular formula:C6H13ClS
Molecular Weight:152.69

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Yield:4303-44-0 94%

Reaction Conditions:

with methanesulfonyl chloride;triethylamine in dichloromethane at 20; for 1 h;

Steps:

12

Intermediate 122-Chloroethyl 1,1-dimethylethyl sulfideA solution of 2-[(1,1-dimethylethyl)thio]ethanol (for example, as prepared for Intermediate 11) in DCM (5 ml) was treated with triethylamine (1 ml, 7 mmol), followed by methanesulfonyl chloride (commercially available, for example, from Aldrich) (0.38 ml, 5 mmol) at room temperature. After 1 h the mixture was diluted with DCM and washed with water (×3), 2 M hydrochloric acid, water, dried (MgSO₄), and evaporated under reduced pressure to give the title compound (354 mg, 94%): ¹H NMR δ (CDCl₃) 3.61 (2H, dd, J=8, 7 Hz), 2.88 (2H, dd, J=8, 7 Hz), 1.31 (9H, s).

References:

US2009/270355,2009,A1 Location in patent:Page/Page column 23

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124-63-0
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Ethanol, 2-[(1,1-dimethylethyl)thio]-, 1-methanesulfonate

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References

29364-29-2
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References