2-(CHLOROMETHYL)-1,3-BENZOTHIAZOLE synthesis
- Product Name:2-(CHLOROMETHYL)-1,3-BENZOTHIAZOLE
- CAS Number:37859-43-1
- Molecular formula:C8H6ClNS
- Molecular Weight:183.66
79-04-9
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$12.00/5g
137-07-5
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$10.00/5g
37859-43-1
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$12.00/250mg
Yield: 86.8%
Reaction Conditions:
for 0.166667 h;Microwave irradiation;
Steps:
Synthesis of 2-Chloromethyl-benzothiazole (4) [27].
To a solution of 2-aminobenzenethiol (1 g,7.93 mmol) in acetic acid (15 mL), and 2-chloroacetyl chloride (1.35 g, 1.19 mmol) was added dropwise.The reaction mixture was irradiated in a microwave oven (Ethos start) for 10 min at a power of 500 W.After cooling, the mixture was poured onto crushed ice (100 mL) and basified with 5 mol/L NaOH.The solution was extracted with chloroform (3 50 mL). The combined organic layers were dried overMgSO4 and concentrated under vacuum. Purification of the residue by column chromatography onsilica gel (petroleum ether/acetone, 10:1 v:v) gave compound 4 as a yellow solid (1.90 g, 86.8%) [27].m.p., 89-90 °C; MS (+ESI) m/z 184.02 [M + H]+.
References:
Luo, Bo;Li, Ding;Zhang, An-Ling;Gao, Jin-Ming [Molecules,2018,vol. 23,# 10,art. no. 2457]
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37859-43-1
115 suppliers
$12.00/250mg
120-75-2
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$10.00/5g
37859-43-1
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$12.00/250mg
51076-95-0
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$43.50/1g
137-07-5
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$10.00/5g
37859-43-1
115 suppliers
$12.00/250mg
70737-12-1
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$83.09/5g
137-07-5
320 suppliers
$10.00/5g
37859-43-1
115 suppliers
$12.00/250mg