2-(CHLOROMETHYL)-5-METHYL-1,3-BENZOXAZOLE synthesis
3synthesis methods
- Product Name:2-(CHLOROMETHYL)-5-METHYL-1,3-BENZOXAZOLE
- CAS Number:41014-44-2
- Molecular formula:C9H8ClNO
- Molecular Weight:181.62
Yield:41014-44-2 75%
Reaction Conditions:
at 0; for 6 h;
Steps:
Synthesis of compounds 1a-1h
General procedure: General Method B: To the solution of substituted 2-aminophenol (1.0 equiv.) or substituted benzene-1, 2-diamine(1.0 equiv.) in DCM (or CH3OH), Int 1 (1.5 equiv.) was added and stirred at 0°C overnight. The mixture was filteredwith celite. The filtrate was concentrated, purified by silica gel chromatography (EtOAc:hexane = 1:1) to afford thedesired products.
References:
Liu, Hao;Chen, Li;Zhou, Fei;Zhang, Yun-Xiao;Xu, Ji;Xu, Meng;Bai, Su-Ping [Bioorganic and Medicinal Chemistry,2019,vol. 27,# 14,p. 3089 - 3096] Location in patent:supporting information
