2-(ChloroMethyl)-5-Methylpyridine hydrochloride synthesis
- Product Name:2-(ChloroMethyl)-5-Methylpyridine hydrochloride
- CAS Number:71670-70-7
- Molecular formula:C7H9Cl2N
- Molecular Weight:178.06
22940-71-2
71670-70-7
General procedure for the synthesis of 2-(chloromethyl)-5-methylpyridine hydrochloride from 2-(hydroxymethyl)-5-methylpyridine: (5-methylpyridin-2-yl)methanol (2-(hydroxymethyl)-5-methylpyridine) was dissolved in SOCl2 (10 mL) and the reaction was carried out at reflux for 30 min. After completion of the reaction, the mixture was concentrated and dried under vacuum to give 2-(chloromethyl)-5-methylpyridine hydrochloride (2.1 g, 91.3% yield) as a white solid.LCMS showed MH+ of 142.
22940-71-2
77 suppliers
$45.00/50mg
71670-70-7
43 suppliers
inquiry
Yield: 91.3%
Reaction Conditions:
with thionyl chloride for 0.5 h;Reflux;
Steps:
50.3 2-(chloromethyl)- -methylpyridine hydrochloride
2-(chloromethyl)- -methylpyridine hydrochloride A solution of (5-methylpyridin-2-yl)methanol in SOCl2 (10 mL) was refluxed 30 min. The mixture was concentrated and dried in vacuo to give 2-(chloromethyl)-5-methylpyridine hydrochloride (2. lg, 91.3% yield) as white solid. LCMS MH+ 142.
References:
HYDRA BIOSCIENCES, INC.;CHENARD, Bertrand;GALLASCHUN, Randall WO2014/143799, 2014, A2 Location in patent:Page/Page column 408; 409
22940-71-2
77 suppliers
$45.00/50mg
7719-09-7
416 suppliers
$15.00/10g
71670-70-7
43 suppliers
inquiry
22940-71-2
77 suppliers
$45.00/50mg
7440-44-0
352 suppliers
$12.00/25g
71670-70-7
43 suppliers
inquiry
4986-05-4
23 suppliers
inquiry
71670-70-7
43 suppliers
inquiry
772-71-4
8 suppliers
inquiry
71670-70-7
43 suppliers
inquiry