2-CYANO-N-(2,4,6-TRIMETHYL-PHENYL)-ACETAMIDE synthesis
1synthesis methods
- Product Name:2-CYANO-N-(2,4,6-TRIMETHYL-PHENYL)-ACETAMIDE
- CAS Number:24578-56-1
- Molecular formula:C12H14N2O
- Molecular Weight:202.25
Yield:-
Reaction Conditions:
Stage #1: cyanoacetic acid;2,4,6-trimethylaniline in tetrahydrofuran at 0;Inert atmosphere;
Stage #2: with diisopropyl-carbodiimide in tetrahydrofuran at 20; for 24 h;Inert atmosphere;
References:
Triola, Gemma;Wetzel, Stefan;Ellinger, Bernhard;Koch, Marcus A.;Huebel, Katja;Rauh, Daniel;Waldmann, Herbert [Bioorganic and Medicinal Chemistry,2009,vol. 17,# 3,p. 1079 - 1087] Location in patent:experimental part