2-CYANO-N-(2,6-DIMETHYL-PHENYL)-ACETAMIDE synthesis
- Product Name:2-CYANO-N-(2,6-DIMETHYL-PHENYL)-ACETAMIDE
- CAS Number:53984-98-8
- Molecular formula:C11H12N2O
- Molecular Weight:188.23
Yield:53984-98-8 83%
Reaction Conditions:
in N,N-dimethyl-formamide; for 12 h;Reflux;Large scale;
Steps:
1.1 Example 1
Step 1: Add 1L of DMF, 0.243Kg of 2,6-dimethylaniline and 0.271Kg of ethyl cyanoacetate to the reaction kettle, and heat to reflux. The reaction was stirred and refluxed for 12 hours. After the reaction, the reaction solution was cooled to room temperature, poured into 8L ice water, stirred for half an hour, filtered with suction, and the filter cake was washed with ethanol. The filter cake was added to 2L of absolute ethanol, heated to reflux and cooled to 0-10 to crystallize for 2 hours, filtered with suction, and the filter cake was dried to prepare Amide compound 0.313Kg, the yield is 83%.
References:
CN112174966,2021,A Location in patent:Paragraph 0011; 0012
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