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1245648-40-1

2-cyclopropyl-6-phenylpyrazine synthesis

2synthesis methods
41270-62-6 Synthesis
2-CHLORO-6-PHENYLPYRAZINE

41270-62-6
54 suppliers
$45.00/10mg

411235-57-9 Synthesis
Cyclopropylboronic acid

411235-57-9
435 suppliers
$6.00/1g

2-cyclopropyl-6-phenylpyrazine

1245648-40-1
5 suppliers
inquiry

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Yield:1245648-40-1 58%

Reaction Conditions:

Stage #1: 6-chloro-2-phenylpyrazine;cyclopropylboronic acidwith tetrakis(triphenylphosphine) palladium(0) in water;toluene at 95; for 0.166667 h;Inert atmosphere;Suzuki Coupling;
Stage #2: with potassium fluoride dihydrate in water;toluene at 95;Inert atmosphere;Suzuki Coupling;

References:

Huang, Wen-Xue;Liu, Lian-Jin;Wu, Bo;Feng, Guang-Shou;Wang, Baomin;Zhou, Yong-Gui [Organic Letters,2016,vol. 18,# 13,p. 3082 - 3085] Location in patent:supporting information