ChemicalBook CAS DataBase List 2-Iodo-4,5-diMethoxybenzaldehyde

2-Iodo-4,5-diMethoxybenzaldehyde synthesis

12synthesis methods

Product Name:2-Iodo-4,5-diMethoxybenzaldehyde
CAS Number:61203-53-0
Molecular formula:C9H9IO3
Molecular Weight:292.07

120-14-9 Synthesis

120-14-9
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Yield:61203-53-0 99%

Reaction Conditions:

with N-iodo-succinimide;trifluoroacetic acid in acetonitrile; for 6 h;Reflux;

Steps:

General procedure: The appropriate benzaldehyde (3 mmol) was dissolved in acetonitrile (5 mL) and N-iodosuccinimide(6 mmol) was added. Trifluoroacetic acid (0.3 μmol) was then added dropwise and the reactionmixture was heated under reflux for 6 h. After cooling to room temperature, the reaction solution wasquenched by the addition of sodium sulfite (3 mmol) and stirred for five minutes. Subsequently,CH2Cl2 (100 mL) was added and the solution was extracted with saturated sodium chloride solution(3 × 100 mL). The organic phase was collected, dried over anhydrous magnesium sulfate, and filtered,and the solvent was removed in vacuo. Column chromatography (petroleum ether-ethyl acetate, 40:1)afforded the corresponding iodinated compound.

References:

Gao, Wenqing;Li, Qingyong;Chen, Jian;Wang, Zhichao;Hua, Changlong [Molecules,2013,vol. 18,# 12,p. 15613 - 15623]