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851384-78-6

(2-IODO-4,5-DIMETHYLPHENYL)METHANOL synthesis

4synthesis methods
35149-23-6 Synthesis
2-Iodo-4,5-dimethylbenzoic acid

35149-23-6
41 suppliers
$95.50/1g

(2-IODO-4,5-DIMETHYLPHENYL)METHANOL

851384-78-6
22 suppliers
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Yield:851384-78-6 91%

Reaction Conditions:

Stage #1: 2-iodo-4,5-dimethylbenzoic acidwith borane-THF in tetrahydrofuran at 0; for 0.5 h;Inert atmosphere;
Stage #2: in tetrahydrofuran; for 2 h;Reflux;Inert atmosphere;

References:

Yi, Duk;Zhu, Feng;Walczak, Maciej A. [Organic Letters,2018,vol. 20,# 15,p. 4627 - 4631] Location in patent:supporting information