2-IODO-PYRIDIN-4-YLAMINE synthesis
- Product Name:2-IODO-PYRIDIN-4-YLAMINE
- CAS Number:88511-26-6
- Molecular formula:C5H5IN2
- Molecular Weight:220.01
7598-35-8
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Yield:-
Reaction Conditions:
with copper(l) iodide;potassium iodide in N,N-dimethyl-formamide at 130;Inert atmosphere;
Steps:
48.1 Step 1: Preparation of 2-iodopyridin-4-amine
2-Bromopyridin-4-amine (400 mg, 2.312 mmol), CuI (881 mg, 4.62 mmol), and KI (1.92 g, 11.56 mmol) were dissolved in DMF (7.7 ml), and the gas was removed by ultrasonic treatment for 10 minutes while blowing nitrogen, followed by stirring at 130° C. overnight. The reaction mixture was filtered with celite, dissolved in excess ethyl acetate, washed with brine, and the organic layer was dried over sodium sulfate and concentrated under reduced pressure. The obtained filtrate was concentrated to give the target compound 2-iodopyridin-4-amine (105.1 mg, 83%), which was used in the next reaction without purification. MS (m/z): 220.95[M+1]+, UPLC r. t. (min): 0.22
References:
US2021/284647,2021,A1 Location in patent:Paragraph 0277-0279
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5029-67-4
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