2-Isopropyl-4-bromo-5-methylphenol synthesis

7synthesis methods

Product Name:2-Isopropyl-4-bromo-5-methylphenol
CAS Number:15062-34-7
Molecular formula:C10H13BrO
Molecular Weight:229.11

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Yield: 82%

Reaction Conditions:

with bromine in acetic acid at 0 - 20; for 6 h;

Steps:

2.1 (1) Synthesis of intermediate 5-methyl-2-isopropyl-4-bromophenol
1.218 g of thymol was dissolved in 20 mL of acetic acid, and the resulting solution was cooled to 0 °C.0.51 mL of Br₂was slowly added over 20 minusing a constant pressure droppingfunnel, and the resulting mixture was stirred at room temperature for a further 6 h.The reactionshould be poured into 50mL of ice water, the extracted three times with 30mL of dichloromethane, the organic phases were combined, dried and concentrated using eluent (Stonepetroleum ether: 1: ethyl acetate = 40) column chromatography to give Intermediate 5 -Methyl-2-isopropyl-4-bromophenol, yield 82%, pale yellowoil.

References:

Yunnan Agricultural University;Su Fawu;Ye Min;Wang Kaibo;Fan Liming;Zha Yougui CN109942427, 2019, A Location in patent:Paragraph 0050-0053

89-83-8 Synthesis

89-83-8
682 suppliers
$5.00/10g