2-METHOXY-6-(TRIFLUOROMETHYL)BENZALDEHYDE synthesis
- Product Name:2-METHOXY-6-(TRIFLUOROMETHYL)BENZALDEHYDE
- CAS Number:1017778-98-1
- Molecular formula:C9H7F3O2
- Molecular Weight:204.15
67-56-1
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60611-24-7
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$10.00/1g
1017778-98-1
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$104.00/1g
Yield:1017778-98-1 1.051 g
Reaction Conditions:
with potassium hydroxide at 60; for 2.5 h;
Steps:
3.1 Step 1: Preparation of 2-methoxy-6-(trifluoromethyl)benzaldehyde
Suspended powdered potassium hydroxide (0.482g)(trifluoromethyl)benzaldehyde (CAS 60611-24-7, 1.5g) in methanoland 2-fluoro-6-(lOmL) and heated to 60°C for 2.5 hours. The mixture was cooled, diluted with water and extracted with ether (x2).The combined organics were washed with water and concentrated to give 2-methoxy-6-(trifluoromethyl)benzaldehyde (1.051g) as a colourless oil which crystallised on standing.1H NMR (400 MHz, ODd3) 6 ppm 10.52 (d, 1H) 7.60 (t, 1H) 7.37 (d, 1H) 7.22 (d, 1H) 3.95(s, 3H)
References:
WO2015/197468,2015,A1 Location in patent:Page/Page column 118
2591-86-8
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454-90-0
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106312-36-1
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1017778-98-1
26 suppliers
$104.00/1g