2-METHYL-2-(METHYLAMINO)PROPANENITRILE synthesis

6synthesis methods

Product Name:2-METHYL-2-(METHYLAMINO)PROPANENITRILE
CAS Number:2273-39-4
Molecular formula:C5H10N2
Molecular Weight:98.15

75-86-5 Synthesis

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74-89-5 Synthesis

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Yield:2273-39-4 63%

Reaction Conditions:

at 20; for 5 h;

Steps:

2.1 (1)
Synthesis of 2-methyl-2-(methylamino)propionitrile

Acetone cyanohydrin (8.5 g, 0.1 mol) was added to a 50 ml four-necked flask, and then methylamine gas (3.1 g, 0.1 mol) was slowly introduced at room temperature.
After that, the reaction was continuously stirred at room temperature for 5 h, and extracted with dichloromethane (10 ml*3).
The organic phase were combined and dried over anhydrous sodium sulfate.
Then, the solvent was removed under reduced pressure to obtain a colorless transparent liquid (6.18 g, yield 63.0%).

References:

US2020/329707,2020,A1 Location in patent:Paragraph 0051-0052