2-Methyl-2-phenyl-2,3-dihydroquinazolin-4(1H)-one synthesis
- Product Name:2-Methyl-2-phenyl-2,3-dihydroquinazolin-4(1H)-one
- CAS Number:957-02-8
- Molecular formula:C15H14N2O
- Molecular Weight:238.28
Yield: 71%
Reaction Conditions:
with tetrahydroxydiboron;acetic acid;copper(l) chloride in methanol;water at 60; for 3 h;
Steps:
29 Example 29
2-Nitrobenzonitrile (0 · 2 mmol, 29 · 6 mg), tetrahydroxydiboron (0.6mmol, 53.8 mg), glacial acetic acid (0.24mmol, 14.5mg), cuprous chloride (0.04mmol, 4.0mg), acetophenone (0·24mmol, 28·8mg), methanol (1ml), water (1ml) were added to the test tube, reacted at 60° C for 3h, after the completion of reaction, the reaction solution was extracted with ethyl acetate three times, the combined organic phases are concentrated to dryness, separated through column chromatography (petroleum ether: ethyl acetate =4:1), Yield:(33.8mg,71%)
References:
China Three Gorges University;Zhou Haifeng;Sui Yuebo;Jiang Xiaolan;Yang Bing;Yu Tao CN108558778, 2018, A Location in patent:Paragraph 0106-0108
