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34874-30-1

2-Methyl-3,4-diethyl-1H-pyrrole synthesis

6synthesis methods
1H-Pyrrole-2-carboxylic acid, 3,4-diethyl-5-methyl-

259176-20-0
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2-Methyl-3,4-diethyl-1H-pyrrole

34874-30-1
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Yield:34874-30-1 45%

Reaction Conditions:

Stage #1: 3,4-Diethyl-5-methylpyrrole-2-carboxylic acidwith trifluoroacetic acid in dichloromethane at 0; for 0.333333 h;Inert atmosphere;
Stage #2: with sodium hydroxide in dichloromethane;water;Cooling with ice;

References:

Smithen, Deborah A.;Cameron, T. Stanley;Thompson, Alison [Organic Letters,2011,vol. 13,# 21,p. 5846 - 5849] Location in patent:supporting information; experimental part