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900182-99-2

2-Methyl-5-(trifluoromethoxy)-1H-indole synthesis

2synthesis methods
Benzoic acid, 2-[[2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl]thio]-

900182-98-1
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2-Methyl-5-(trifluoromethoxy)-1H-indole

900182-99-2
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Yield:900182-99-2 59%

Reaction Conditions:

Stage #1: 2-{[2-methyl-5-(trifluoromethoxy)-1H-indole-3-yl]thio}benzoic acidwith Thiosalicylic acid;trifluoroacetic acid at 50; for 3 h;
Stage #2: with sodium hydroxide in water;ethyl acetate;

References:

WO2006/75638,2006,A1 Location in patent:Page/Page column 65

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