Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
logo
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook

Welcome back!

Structured search
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 2-Methyl-8-(pyridin-2-yl)benzofuro[2,3-b]pyridine
1609373-99-0

2-Methyl-8-(pyridin-2-yl)benzofuro[2,3-b]pyridine synthesis

9synthesis methods
109-04-6 Synthesis
2-Bromopyridine

109-04-6
533 suppliers
$6.00/25g

1609374-04-0 Synthesis
2-methyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuro[2,3-b]pyridine

1609374-04-0
36 suppliers
inquiry

2-Methyl-8-(pyridin-2-yl)benzofuro[2,3-b]pyridine

1609373-99-0
75 suppliers
inquiry

-

Yield:1609373-99-0 80%

Reaction Conditions:

Stage #1: 2-bromo-pyridine;2-methyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuro[2,3-b]pyridinewith potassium carbonate in tetrahydrofuran; for 0.5 h;Inert atmosphere;
Stage #2: with tetrakis(triphenylphosphine) palladium(0) at 80; for 12 h;

Steps:

4 4. Synthesis of Ligand L-2

Under the protection of nitrogen,Add intermediate I-1 (10 g, 32.3 mmol) to a three-neck bottle.2-bromopyridine (6.1 g, 38.8 mmol), 2M-potassium carbonate (80 mL)Dissolved in tetrahydrofuran (80 mL). Nitrogen replacement for 30 minutes,The catalyst tetrakistriphenylphosphine palladium (3 mol%) was added. The reaction system was warmed to 80 ° C and stirred under reflux for 12 hours.After cooling to room temperature, the reaction mixture was quenched with water and ethyl acetate and brine. Wash two to three times with saturated brine and take the organic phase.The organic phase was dried over anhydrous magnesium sulfate and concentrated.Separation and purification by silica gel column to obtain ligand L-2(6.7 g, yield: 80%).

References:

CN109810146,2019,A Location in patent:Paragraph 0086-0088

109-04-6 Synthesis
2-Bromopyridine

109-04-6
533 suppliers
$6.00/25g

1609373-98-9 Synthesis
2-Methylbenzofuro[2,3-b]pyridin-8-yl trifluoromethanesulfonate

1609373-98-9
73 suppliers
inquiry

2-Methyl-8-(pyridin-2-yl)benzofuro[2,3-b]pyridine

1609373-99-0
75 suppliers
inquiry

References
1609373-96-7 Synthesis
8-methoxy-2-methylbenzofuro[2,3-b]pyridine

1609373-96-7
3 suppliers
inquiry

2-Methyl-8-(pyridin-2-yl)benzofuro[2,3-b]pyridine

1609373-99-0
75 suppliers
inquiry

References
2-Amino-6-methylpyridine

1824-81-3
486 suppliers
$8.00/25g

2-Methyl-8-(pyridin-2-yl)benzofuro[2,3-b]pyridine

1609373-99-0
75 suppliers
inquiry

References
2,3-Dimethoxyphenylboronic acid

40972-86-9
236 suppliers
$10.00/1g

2-Methyl-8-(pyridin-2-yl)benzofuro[2,3-b]pyridine

1609373-99-0
75 suppliers
inquiry

References

2-Methyl-8-(pyridin-2-yl)benzofuro[2,3-b]pyridine Related Search:

Thianaphthene Dibenzofuran