2-Methyl-N-[(trimethylsilyl)methyl]-2-propanamine synthesis
- Product Name:2-Methyl-N-[(trimethylsilyl)methyl]-2-propanamine
- CAS Number:79250-80-9
- Molecular formula:C8H21NSi
- Molecular Weight:159.34
75-64-9
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2344-80-1
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79250-80-9
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$60.00/1g
Yield:79250-80-9 96%
Reaction Conditions:
Stage #1: tert-butylamine;Chloromethyltrimethylsilane at 200; for 18 h;
Stage #2: with sodium hydroxide in water;
Steps:
1
A solution of (chloromethyl)trimethylsilane (50 g, 408 mmol) and tert-butylamine (130 mL) under dry nitrogen was heated at 200° C. in a sealed tube for 18 hours before being quenched by the addition of 2M sodium hydroxide solution (700 mL). The resulting mixture was extracted with diethyl ether (3×100 mL) and the combined organic layers were distilled under dry nitrogen at 1 atmosphere to afford the title compound as a clear oil (62 g, 96%). 1H NMR (CDCl3, 400 MHz) δ 0.05 (s, 9H), 1.05 (s, 9H), 1.95 (s, 2H).
References:
US2008/234280,2008,A1 Location in patent:Page/Page column 28
4206-67-1
144 suppliers
$15.00/1g
75-64-9
444 suppliers
$10.00/10g
79250-80-9
11 suppliers
$60.00/1g