ChemicalBook CAS DataBase List 2-Methylbenzene-1-sulfonamide

2-Methylbenzene-1-sulfonamide synthesis

9synthesis methods

Product Name:2-Methylbenzene-1-sulfonamide
CAS Number:88-19-7
Molecular formula:C7H9NO2S
Molecular Weight:171.22

Benzenediazonium, 2-methyl-, tetrafluoroborate(1-)

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Yield:88-19-7 70%

Reaction Conditions:

with sodium metabisulfite;sodium azide;tetrabutylammomium bromide;triphenylphosphine in water;acetonitrile at 80; for 12 h;Inert atmosphere;Schlenk technique;

Steps:

14 Synthesis of compound 2n:
Under nitrogen protection,Diazonium salt 1n (257.4 mg, 1.25 mmol), NaN3 (32.5 mg, 0.5 mmol), PPh3 (157.4 mg, 0.6 mmol), Na2S2O5 (190.1 mg, 1.0 mmol), TBAB (241.7 mg, 0.75 mmol) and MeCN /H2O=2/1 (1 mL) was added to the Schlenk reaction tube. After the reaction was stirred at 80 ° C for 12 h,Reduce to room temperature, add 10mL water to the system to dilute,Extracted with ethyl acetate (10 mL*3), dried over anhydrous sodiumColumn chromatography gave 2n (70%) as a colourless oil.

References:

East China Normal University;Jiang Xuefeng;Wang Ming;Fan Qiaoling CN109438296, 2019, A Location in patent:Paragraph 0094-0097

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133-59-5 Synthesis