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ChemicalBook CAS DataBase List 2-MethyliMidazo[1,2-a]pyrazine
33668-80-3

2-MethyliMidazo[1,2-a]pyrazine synthesis

2synthesis methods
-

Yield:-

Reaction Conditions:

in ethanol at 75; for 1 h;

Steps:

1 2-methyl-imidazo[1,2-a]pyrazine

Example 1 2-methyl-imidazo[1,2-a]pyrazine Bromo-propan-2-one (1.48 g) and pyrazin-2-ylamine (0.93) g in EtOH were heated to 75 C for 1 h. The reaction mixture was cooled, concentrated under reduced pressure and purified on a silica gel column (10% MeOH/DCM) to yield 1.8 g of 2-methyl-imidazo[1,2-a]pyrazine.

References:

US2011/301170,2011,A1 Location in patent:Page/Page column 23-24