2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE synthesis
- Product Name:2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE
- CAS Number:1074-68-6
- Molecular formula:C6H6N2OS
- Molecular Weight:154.19
497-19-8
1371 suppliers
$13.00/300G
180869-36-7
72 suppliers
$32.00/1g
1074-68-6
143 suppliers
$20.00/100mg
Yield: 7.49 g (97%)
Reaction Conditions:
with hydrogenchloride in ethyl acetate
Steps:
1.b b
b 2-Methylthiopyrimidine-4-carboxaldehyde The product of example 1(a) (9.96 g, 50 mmol), and 3 N HCl (42 mL, 126 mmol) were combined and stirred at 48° C. for 16 h, cooled to 23° C., combined with EtOAc (200 mL) and made basic by the addition of solid Na2 CO3 (12.6 g, 150 mmol). The aqueous phase was extracted with EtOAc (4*150 mL, dried (Na2 SO4), concentrated and the residue was filtered through a pad of silica (ca 150 mL) with CH2 Cl2 to afford 7.49 g (97%) of the title compound 1 H NMR (CDCl3): δ9.96 (s,1), 8.77 (d, 1), 7.44 (d, 1), 2.62 (s,3).
References:
SmithKline Beecham Corporation US5977103, 1999, A
180869-36-7
72 suppliers
$32.00/1g
1074-68-6
143 suppliers
$20.00/100mg
6342-56-9
304 suppliers
$8.00/25g
180869-36-7
72 suppliers
$32.00/1g
74-88-4
339 suppliers
$15.00/10g
1074-68-6
143 suppliers
$20.00/100mg