(2-PHENYL-1,3-THIAZOL-4-YL)ACETONITRILE synthesis
- Product Name:(2-PHENYL-1,3-THIAZOL-4-YL)ACETONITRILE
- CAS Number:16441-25-1
- Molecular formula:C11H8N2S
- Molecular Weight:200.26
Yield:16441-25-1 69%
Reaction Conditions:
in ethanol; for 4 h;Reflux;
Steps:
1.2 (2) Preparation of intermediate 2-phenyl-4-cyanomethylthiazole
Was added at room temperature to a 50 ml round bottom flask3-chloromethyl-2-phenylthiazole (2.10 g, 0.010 mol),Add ethanol 50 ml fully dissolved,Sodium cyanide (0.59 g, 0.012 mol) was added,The temperature was raised to reflux and the reaction was kept under reflux for 4 hours.After the reaction was stopped,Naturally cooled to room temperature,Poured into 100 ml of water,Extracted with 3 x 30 ml ethyl acetate,The organic phase was washed with 3 x 50 ml saturated aqueous sodium chloride solution,Dried over anhydrous magnesium sulfate,After concentration, the residue was chromatographed (eluent: ethyl acetate: petroleum ether = 1: 5) to give 1.38 g of 2-phenyl-4-cyanomethylthiazole,Yellow solid, yield 69%.
References:
CN103833742,2016,B Location in patent:Paragraph 0078; 0079; 0080
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