(2-PIPERIDIN-1-YL-PHENYL)METHANOL synthesis
- Product Name:(2-PIPERIDIN-1-YL-PHENYL)METHANOL
- CAS Number:87066-94-2
- Molecular formula:C12H17NO
- Molecular Weight:191.27
34595-26-1
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87066-94-2
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Yield:87066-94-2 572 mg
Reaction Conditions:
Stage #1: 2-(piperidin-1-yl)benzaldehydewith sodium tetrahydroborate in ethanol; for 1 h;Cooling with ice;
Stage #2: with acetic acid in ethanol;
Steps:
34.2
(2) To a solution of the Compound 3 (568 mg) in ethanol (6 mE) was added sodium borohydride (114 mg) under ice- cooling, and the resulting mixture was stirred at the same temperature for 1 hout To the reaction mixture was addedacetic acid, and the resulting mixture was stirred, and then concentrated under reduced pressure. To the resulting residues were added ethyl acetate and a saturated aqueous solution of sodium hydrogen carbonate, and the resulting mixture was stirred, and then extracted with ethyl acetate. The resulting organic layers were washed with saturated brine, dried, and concentrated under reduced pressure to give the Compound 4 (572 mg) as a pale yellow liquid. MS (APCI): mlz 192 [M+H]
References:
US2018/258076,2018,A1 Location in patent:Paragraph 0496
446-52-6
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87066-94-2
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110-89-4
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87066-94-2
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81215-42-1
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87066-94-2
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394-35-4
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87066-94-2
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$20.00/100mg