2-[(PYRIDIN-3-YLMETHYL)-AMINO]-ETHANOL synthesis
- Product Name:2-[(PYRIDIN-3-YLMETHYL)-AMINO]-ETHANOL
- CAS Number:70206-51-8
- Molecular formula:C8H12N2O
- Molecular Weight:152.19
500-22-1
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Yield:70206-51-8 936 mg
Reaction Conditions:
Stage #1: 3-pyridinecarboxaldehyde;ethanolamine in methanol at 60; for 2 h;
Stage #2: with methanol;sodium tetrahydroborate at 60; for 2 h;Cooling with ice;
Steps:
56.56-1 Example 56 (56-1) 2-[(Pyridine-3-ylmethyl) Amino] Ethanol (Example Compound 56-1)
2-Aminoethanol (400 mg)Is dissolved in methanol (10 mL) andAdd 3-pyridinecarbaldehyde (702 mg) and addThe mixture was stirred at 60 ° C. for 2 hours. Sodium borohydride (248 mg) was added to the mixed solution under ice-cooling, and thenThe mixture was stirred at 60 ° C. for 5 hours.After the reaction solution was brought to room temperature, the reaction solution was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (chloroform: methanol = 100: 0 to 95: 5) to give the title compound (936 mg) as a pale yellow oil.
References:
JP2021/80183,2021,A Location in patent:Paragraph 0693-0695
![Ethanol, 2-[(3-pyridinylmethylene)amino]-](/CAS/20210305/GIF/71006-03-6.gif)
71006-03-6
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70206-51-8
22 suppliers
$45.00/25mg
500-22-1
509 suppliers
$6.00/5g
70206-51-8
22 suppliers
$45.00/25mg