2-Pyridinecarboxylic acid, 4-(phenylmethoxy)- synthesis
- Product Name:2-Pyridinecarboxylic acid, 4-(phenylmethoxy)-
- CAS Number:100727-49-9
- Molecular formula:C13H11NO3
- Molecular Weight:229.23
100382-00-1
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Yield:100727-49-9 62.5%
Reaction Conditions:
with water;sodium hydroxide in ethanol at 90; for 1 h;
Steps:
3 Step 3: 4-(benzyloxy)picolinic acid
To a solution of 4-(benzyloxy)picolinonitrile (2.2 g, 10.46 mmol) in ethanol (15 mL) was added 10% aqueous sodium hydroxide solution (15 mL). The reaction was stirred at 90°C for 1 hr. The resulting mixture was cooled to room temperature and acidified by adding2M hydrochloric acid to pH3. The mixture was filtered and the filter cake was washed with water and dried under vacuum to give 4-(benzyloxy)picolinic acid (1.5 g, 62.5% yield) as white solid. LC-MS (ESI) found: 230 [M+Hj
References:
WO2018/31877,2018,A1 Location in patent:Paragraph 00183
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