2-Pyrimidinemethanol, alpha-methyl- (9CI) synthesis
- Product Name:2-Pyrimidinemethanol, alpha-methyl- (9CI)
- CAS Number:53342-30-6
- Molecular formula:C6H8N2O
- Molecular Weight:124.14
53342-27-1
151 suppliers
$21.00/250mg
53342-30-6
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$155.00/50mg
Yield:53342-30-6 88%
Reaction Conditions:
with sodium tetrahydroborate in methanol at 20; for 1 h;
Steps:
7
EXAMPLE 7 (0496) (0497) To a solution of Compound 21 (390 mg, 3.19 mmol) in MeOH (4 ml) was added sodium borohydride (60 mg, 1.60 mmol), and the obtained reaction mixture was stirred at room temperature for one hour. The solvent was removed by distillation under reduced pressure, followed by dilution with a saturated aqueous solution of ammonium chloride, and extraction with ethyl acetate. The organic layer was washed with a saturated aqueous solution of ammonium chloride and brine and dried with sodium sulfate. The solvent was then removed by distillation under reduced pressure to obtain Compound 22 (350 mg, 88%) as a colorless oil. Compound 22; 1H-NMR (CDCl3) δ: 1.58 (d, J=6.65 Hz, 3H), 4.18 (s, 1H), 4.97 (q, J=6.65 Hz, 1H), 7.24 (t, J=4.89 Hz, 1H), 8.75 (d, J=4.89 Hz, 2H).
References:
US9567330,2017,B2 Location in patent:Page/Page column 45
4595-59-9
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29786-93-4
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75-07-0
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$14.00/5mL
53342-30-6
22 suppliers
$155.00/50mg
14080-23-0
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$8.00/10g
53342-30-6
22 suppliers
$155.00/50mg