2-Cyanopyrimidine
- CAS No.
- 14080-23-0
- Chemical Name:
- 2-Cyanopyrimidine
- Synonyms
- PYRIMIDINE-2-CARBONITRILE;2-PYRIMIDINECARBONITRILE;2CPM;2-CPY;2-cyanpyrimidine;2-Cynopyrimidine;2-CYANOPYRIMIDINE;Bosentan Impurity 14;Bosentan Impurity 15;2-Cyanopyrimidine >
- CBNumber:
- CB1431357
- Molecular Formula:
- C5H3N3
- Molecular Weight:
- 105.1
- MDL Number:
- MFCD00160513
- MOL File:
- 14080-23-0.mol
- MSDS File:
- SDS
| Melting point | 40-44 °C (lit.) |
|---|---|
| Boiling point | 250.7±23.0 °C(Predicted) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | -3.27±0.13(Predicted) |
| form | Crystalline Powder |
| color | White to yellow |
| InChIKey | IIHQNAXFIODVDU-UHFFFAOYSA-N |
| CAS DataBase Reference | 14080-23-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H317 | |||||||||
| Precautionary statements | P280-P301+P310+P330-P302+P352 | |||||||||
| Hazard Codes | Xn,C,F,T | |||||||||
| Risk Statements | 22-37/38-41-43-34-11-25 | |||||||||
| Safety Statements | 26-36/37/39-45-16-36/37 | |||||||||
| RIDADR | 3276 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
2-Cyanopyrimidine price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 646830 | 2-Pyrimidinecarbonitrile 97% | 14080-23-0 | 5g | $37.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 646830 | 2-Pyrimidinecarbonitrile 97% | 14080-23-0 | 25g | $50 | 2024-03-01 | Buy |
| TCI Chemical | C1518 | 2-Cyanopyrimidine >98.0%(GC) | 14080-23-0 | 1g | $24 | 2024-03-01 | Buy |
| TCI Chemical | C1518 | 2-Cyanopyrimidine >98.0%(GC) | 14080-23-0 | 5g | $55 | 2024-03-01 | Buy |
| Cayman Chemical | 10007121 | 2-cyano-Pyrimidine >98% | 14080-23-0 | 500mg | $11 | 2024-03-01 | Buy |
2-Cyanopyrimidine Chemical Properties,Uses,Production
Chemical Properties
White to yellow to brown solid
Biological Activity
2-cyano-pyrimidine is a cathepsin k inhibitor.cathepsin k is a protease defined by its high specificity for kinins, which is involved in bone resorption. cathepsin k's ability to catabolize collagen, elastin, and gelatin allow it to break down bone and cartilage. such catabolic activity is also partially responsible for the loss of lung elasticity and recoil in emphysema. therefore, inhibitors of cathepsin k are showing great potential in the treatment of osteoporosis.
in vitro
2-cyano-pyrimidine was identified as a cathepsin k inhibitor whose basic structure and derivatives have been evaluated for the treatment of osteoporosis. enzymatic study showed that 2-cyano-pyrimidine had an ic50 value of 170 nm for inhibition of cathepsin k, elevated activity of which has been linked to the formation of osteoporosis and arthritis. moreover, cathepsin k was found to be a lysosomal cysteine protease found in osteoclasts. [1,2].
IC 50
170 nm
References
[1] altmann, e. ,aichholz, r.,betschart, c., et al. 2-cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin k. journal of medicinal chemistry 50(4), 591-594 (2007).
[2] rankovic z et al. design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin k inhibitors. bioorg med chem lett. 2010 mar 1;20(5):1524-7.
2-Cyanopyrimidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 6710 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 925 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
View Lastest Price from 2-Cyanopyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-12 | 2-Cyanopyrimidine
14080-23-0
|
US $20.00-179.00 / g | 1g | 0.99 | 10kg | Shanghai UCHEM Inc. | |
 |
2023-11-01 | 2-Cyanopyrimidine
14080-23-0
|
US $0.00 / kg | 1kg | 99.0% min | 10tons/month | Hangzhou ICH Biofarm Co., Ltd | |
 |
2023-08-16 | 2-Cyanopyrimidine
14080-23-0
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- 2-Cyanopyrimidine
14080-23-0
- US $20.00-179.00 / g
- 0.99
- Shanghai UCHEM Inc.
-
- 2-Cyanopyrimidine
14080-23-0
- US $0.00 / kg
- 99.0% min
- Hangzhou ICH Biofarm Co., Ltd
-
- 2-Cyanopyrimidine
14080-23-0
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd