1,3,4-Oxadiazol-2(3H)-one, 3-[(5-chloro-2-methoxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]- synthesis
- Product Name:1,3,4-Oxadiazol-2(3H)-one, 3-[(5-chloro-2-methoxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-
- CAS Number:202822-68-2
- Molecular formula:C17H12ClF3N2O3
- Molecular Weight:384.74
![5-[4-(Trifluoromethyl)phenyl]-3H-1,3,4-oxadiazol-2-one](/CAS/20200611/GIF/202823-22-1.gif)
Yield:202822-68-2 92%
Reaction Conditions:
with sodium hydride in N,N-dimethyl-formamide;mineral oil at 60; for 18 h;Inert atmosphere;
Steps:
7.1 Synthesis of 3-((5-chloro-2-methoxyphenyl)methyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)-one
A solution of intermediate 5- (4- (trifluoromethyl) phenyl) -1,3,4-oxadiazol-2 (3-hydro) -one (product of Example 1)6.5 mmol and intermediate 2- (bromomethyl) -4-chloro-1-methoxybenzene (product from Example 5)6.5 mmol Under the protection of a nitrogen stream,Dissolved in anhydrous DMF,Sodium hydride was added to 6.5 mmol,After stirring at 60 ° C for 18 hours,Poured into 100mL water,The intermediate 3- (5-chloro-2-methoxyphenyl) -5- (4-trifluoromethylphenyl) -1,3,4-oxadiazol-2 (3-hydro) (Compound 5) 6 mmol,Yield 92%.
References:
CN104710379,2017,B Location in patent:Paragraph 0064; 0066; 0067
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