4-CHLORO-2-(CHLOROMETHYL)-1-METHOXYBENZENE synthesis
- Product Name:4-CHLORO-2-(CHLOROMETHYL)-1-METHOXYBENZENE
- CAS Number:7035-11-2
- Molecular formula:C8H8Cl2O
- Molecular Weight:191.05
7035-10-1
32 suppliers
$190.00/1g
7035-11-2
22 suppliers
$318.00/1g
Yield:7035-11-2 98%
Reaction Conditions:
with thionyl chloride in dichloromethane at 0 - 20; for 16.1667 h;
Steps:
44.5
4-Chloro-2-chloromethyl-1-methoxy-benzene, used in step 1, was prepared as follows: A cooled (0° C.) solution of (5-chloro-2-methoxy-phenyl)-methanol (4.54 g, 26.3 mmol) in dichloromethane (50 mL) was treated with thionyl chloride (2.01 mL, 27.7 mmol), which was added dropwise over 10 min. The mixture was stirred at room temperature for 16 h, then partitioned between diethyl ether and water. The organic phase was dried with sodium sulphate and evaporated. The residue was pure 4-chloro-2-chloromethyl-1-methoxy-benzene, 4.93 g (98%), and was used as such.
References:
US2008/103182,2008,A1 Location in patent:Page/Page column 21
3438-16-2
218 suppliers
$5.00/1g
7035-11-2
22 suppliers
$318.00/1g
50-00-0
891 suppliers
$10.00/25g
623-12-1
287 suppliers
$10.00/25g
7035-11-2
22 suppliers
$318.00/1g
635-93-8
358 suppliers
$6.00/5g
7035-11-2
22 suppliers
$318.00/1g
7035-09-8
146 suppliers
$25.00/1g
7035-11-2
22 suppliers
$318.00/1g