TERT-BUTYL 4-[3-(METHOXYCARBONYL)BENZYL!PIPERAZINE-1-CARBOXYLATE, 97+% synthesis

Yield:203047-36-3 86%

Reaction Conditions:

with triethylamine in dichloromethane at 20; for 24 h;

Steps:

18.A 18A: tert-Butyl 4-(3-(methyloxycarbonyl)benzyl)piperazine-1-carboxylate

Methyl 3-(bromomethylbenzoate) (1.23 g, 5.37 mmol) was added to a stirred solution of tert-butyl piperazine-1-carboxylate (1.00 g, 5.37 mmol) and triethylamine (1.50 ml, 10.74 mmol) in dichloromethane (20 ml). The solution was stirred at room temperature for 24h then concentrated in vacuo. The residue was purified by flash chromatography on silica gel (eluant EtOAc) to give a white solid identified as tert-butyl 4-(3-(methyloxycarbonyl)benzyl)-piperazine-1-carboxylate (1.55 g, 86%).

References:

EP1449844,2004,A1 Location in patent:Page 31