2-(2-CHLORO-ACETYLAMINO)-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID AMIDE synthesis
- Product Name:2-(2-CHLORO-ACETYLAMINO)-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID AMIDE
- CAS Number:20886-87-7
- Molecular formula:C11H13ClN2O2S
- Molecular Weight:272.75
79-04-9
383 suppliers
$12.00/5g
4815-28-5
160 suppliers
$10.00/500mg
20886-87-7
26 suppliers
$28.60/10MG
Yield:20886-87-7 84%
Reaction Conditions:
with triethylamine at 0 - 20; for 2 h;
Steps:
10 Example 10: r4-('Cvclopropyl-methyl-amino -5,6,7,8-tetrahvdro-benzor4,51thienor2,3- dlpyrimidin-2-vH -methanol (Compound 49)
Example 10: r4-('Cvclopropyl-methyl-amino -5,6,7,8-tetrahvdro-benzor4,51thienor2,3- dlpyrimidin-2-vH -methanol (Compound 49) To a mixture of 2-amino-4,5,6,7-tetrahydro-l-benzothiophene-3-carboxamide (30 g, 0.153 mol) and triethylamine (18.5g, 0.183mol) in DCM (200 ml) was added chloro-acetyl chloride (20.57 g, 0.183 mol) slowly at 0 C, and the resulting mixture was stirred at room temperature for 2h. The reaction mixture was concentrated to half of the volume to afford the solid product which was filtered, washed with 10 ml of DCM and dried to provide 2-(2- chloro-acetylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide (35 g, 84%) as off-white solid. XH NMR (400 MHz, DMSO-d6): δ 1.65-1.75 (m, 4H), 2.58-2.72 (m, 4H), 4.49 (s, 2H), 7.29 (s, 1H), 7.42 (s, 1H), 12.23 (s, 1H); LC-MS: [M+H] = 272.8, 275.1, 257.9 & 255.9 m/z.
References:
WO2013/112651,2013,A2 Location in patent:Page/Page column 64
108-94-1
577 suppliers
$12.00/50g
20886-87-7
26 suppliers
$28.60/10MG
![ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE](/CAS/GIF/4506-71-2.gif)
4506-71-2
203 suppliers
$6.00/1g
79-04-9
383 suppliers
$12.00/5g
20886-87-7
26 suppliers
$28.60/10MG