N-{2-chloro-4-[(2-hydroxy-2-methylpropyl)amino]quinolin-3-yl}-2-ethoxyacetamide synthesis

5synthesis methods

Product Name:N-{2-chloro-4-[(2-hydroxy-2-methylpropyl)amino]quinolin-3-yl}-2-ethoxyacetamide
CAS Number:253120-65-9
Molecular formula:C17H22ClN3O3
Molecular Weight:351.83

133860-78-3 Synthesis

2-Propanol, 1-[(3-amino-2-chloro-4-quinolinyl)amino]-2-methyl-

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N-{2-chloro-4-[(2-hydroxy-2-methylpropyl)amino]quinolin-3-yl}-2-ethoxyacetamide

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Yield:253120-65-9 50%

Reaction Conditions:

with triethylamine in dichloromethane; for 3 h;

Steps:

6 Preparation of compound 2-6

Preparation of compound 2-6 To a solution of 2-5 (5.7 g, 21.5 mmol) and TEA (4 g, 40 mmol) in DCM( 100 mL) was added compound 2-ethoxyacetyl chloride (3 g). The mixture was stirred for 3hrs, and then it was washed with sat. brine. The organic layer was concentrated and theresidue was purified by silica gel column chromatography (EA: PE=1 :2). The desiredproduct was obtained (3.7 g, 50%).

References:

WO2013/67597,2013,A1 Location in patent:Page/Page column 79

1-[(2-chloro-3-nitro-4-quinolinyl)amino]-2-methyl-2-propanol

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References

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70254-44-3 Synthesis

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