6,7-dihydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3(5H)-one synthesis
- Product Name:6,7-dihydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3(5H)-one
- CAS Number:25823-52-3
- Molecular formula:C13H12N2O
- Molecular Weight:212.25
![4a,5,6,7-tetrahydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3(4H)-one](/CAS/20180529/GIF/25742-87-4.gif)
25742-87-4
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25823-52-3
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Yield:25823-52-3 90%
Reaction Conditions:
with copper dichloride in acetonitrile; for 2 h;Product distribution / selectivity;Heating / reflux;
Steps:
7.A
SYNTHETIC PREPARATION 7; Synthesis of 3-oxo-6,7-dihydro-5/-/-benzo[6,7]cyclohepta[1 ,2-c]pyridazineCompound of formula (De)A. A mixture of the compound of formula (Dd), 4a,5,6,7-tetrahydro-2H- benzo[6,7]cyclohepta[c]pyridazin-3(4H)-one (4.7 g, 22 mmol) and anhydrous copper(ll) chloride (6 g, 44 mmol) was refluxed in acetonitrile (45 mL) for 2 hours. After cooling to ambient temperature, the mixture was poured into ice-water (200 g) and the solid obtained was washed with 10% HCI solution twice (about 20 mLx2) and cold water twice (about 20 mLx2). After freeze-drying, the compound of formula (De), 3-oxo-6,7- dihydro-5H-benzo[6,7]cyclohepta[1 ,2-c]pyridazine (4.2 g, 90%) was obtained as a white solid, 1H NMR (300 MHz, CDCI3) δ: 10.80 (bs, 1 H), 7.53-7.21 (m, 4H), 6.77 (s, 1 H), 2.66 (t, J = 6.9 Hz, 2H), 2.45 (t, J = 6.9 Hz, 2H), 2.14 (quant, J = 6.9 Hz, 2H); LC- MS: purity: 100%; MS (m/e) : 213 (MH+).
References:
WO2008/83353,2008,A1 Location in patent:Page/Page column 126
127-68-4
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25742-87-4
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25823-52-3
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826-73-3
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298-12-4
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25823-52-3
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$73.00/100mg
826-73-3
156 suppliers
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25823-52-3
30 suppliers
$73.00/100mg
25742-81-8
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25823-52-3
30 suppliers
$73.00/100mg