1-CHLOROACETYL-4-(3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YL)PIPERAZINE synthesis
- Product Name:1-CHLOROACETYL-4-(3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YL)PIPERAZINE
- CAS Number:260553-15-9
- Molecular formula:C12H12Cl2F3N3O
- Molecular Weight:342.14
79-04-9
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$12.00/5g
![1-[3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YL]PIPERAZINE](/CAS/GIF/132834-59-4.gif)
132834-59-4
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$15.00/250mg
260553-15-9
24 suppliers
$399.00/500mg
Yield:260553-15-9 26.53 g
Reaction Conditions:
with triethylamine in ethyl acetate at 20; for 1 h;
Steps:
2.1 (1) Synthesis of intermediate IIc
Intermediate III 21.24g (0.08 mol) was added to a 250 mL single-mouth bottle.50 g of ethyl acetate and 10 g of triethylamine.Magnetic stirring, adding 9.04 g (0.08 mol) of chloroacetyl chloride.The reaction was carried out at room temperature for 1 h, and the TLC followed the reaction completely.Add water to separate the liquid, dry with anhydrous sodium sulfate,Ethyl acetate was removed by rotary evaporation.It was cooled to a white solid IIc 26.53 g.
References:
CN109336882,2019,A Location in patent:Paragraph 0034; 0035; 0036; 0037
69045-84-7
409 suppliers
$10.00/5g
260553-15-9
24 suppliers
$399.00/500mg