ChemicalBook CAS DataBase List 1-CHLOROACETYL-4-(3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YL)PIPERAZINE

1-CHLOROACETYL-4-(3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YL)PIPERAZINE synthesis

2synthesis methods

Product Name:1-CHLOROACETYL-4-(3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YL)PIPERAZINE
CAS Number:260553-15-9
Molecular formula:C12H12Cl2F3N3O
Molecular Weight:342.14

79-04-9 Synthesis

79-04-9
350 suppliers
$12.00/5g

132834-59-4 Synthesis

1-[3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YL]PIPERAZINE

132834-59-4
75 suppliers
$15.00/250mg

1-CHLOROACETYL-4-(3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YL)PIPERAZINE

260553-15-9
21 suppliers
$399.00/500mg

Yield:260553-15-9 26.53 g

Reaction Conditions:

with triethylamine in ethyl acetate at 20; for 1 h;

Steps:

2.1 (1) Synthesis of intermediate IIc

Intermediate III 21.24g (0.08 mol) was added to a 250 mL single-mouth bottle.50 g of ethyl acetate and 10 g of triethylamine.Magnetic stirring, adding 9.04 g (0.08 mol) of chloroacetyl chloride.The reaction was carried out at room temperature for 1 h, and the TLC followed the reaction completely.Add water to separate the liquid, dry with anhydrous sodium sulfate,Ethyl acetate was removed by rotary evaporation.It was cooled to a white solid IIc 26.53 g.

References:

CN109336882,2019,A Location in patent:Paragraph 0034; 0035; 0036; 0037

2,3-Dichloro-5-(trifluoromethyl)pyridine

69045-84-7
389 suppliers
$10.00/5g

260553-15-9
21 suppliers
$399.00/500mg

References