2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE synthesis
- Product Name:2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE
- CAS Number:26493-11-8
- Molecular formula:C6H7N3OS
- Molecular Weight:169.2
![2-AMino-4-oxo-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester](/CAS/20150408/GIF/1312412-88-6.gif)
1312412-88-6
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26493-11-8
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Yield:26493-11-8 96%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane at 20; for 3 h;
Steps:
II(c).i; 3.i Step i: 2-amino-6,7-diriydrothiazolor5,4-clpyridin-4(5H)-one
Step i: 2-amino-6,7-diriydrothiazolor5,4-clpyridin-4(5H)-one
To a 50 mL round bottom flask, were added tert-butyl 2-amino-4-oxo-6,7-dihydrothiazolo[5,4- c]pyridine-5(4H)-carboxylate [intermediate 4 of scheme 11(a)] (0.7 g, 0.0026 mol) and 1,4- dioxane. To the same flask, hydrochloric acid in 1,4-dioxane (10 mL) was added. The reaction mixture was stirred at RT for 3 h. The volatiles were evaporated under reduced pressure to get solid. The solid was washed with diethyl ether to get the title compound [0.4 g, 96 %]. LC-MS: 169.9 [M+H]+.
References:
WO2015/101928,2015,A1 Location in patent:Page/Page column 66; 67
1312412-87-5
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$80.00/100mg
17356-08-0
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26493-11-8
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845267-78-9
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26493-11-8
47 suppliers
$58.00/100mg
1312412-87-5
29 suppliers
$80.00/100mg
26493-11-8
47 suppliers
$58.00/100mg