4-HYDROXY-8-METHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER synthesis
- Product Name:4-HYDROXY-8-METHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
- CAS Number:27568-04-3
- Molecular formula:C13H13NO4
- Molecular Weight:247.25
104007-09-2
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27568-04-3
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Yield: 64%
Reaction Conditions:
in diphenyl ether-biphenyl eutectic at 250;
Steps:
83.B
Step B: Ethyl 4-hydroxy-8-methoxyquinoline-3-carboxylate: 2-((2-methoxyphenylamino)methylene)malonate (47.6 g, 162 mmol) was suspended in Dowtherm (100 mL) and heated to 250° C. in a sand bath overnight, then cooled to ambient temperature and diluted with pentane (750 mL). The solid was collected by filtration and washed with hexanes (25.7 g, 64%). MS (APCI) m/z 248.0 (M+1).
References:
Miknis, Greg;Lyssikatos, Joseph P.;Laird, Ellen;Tarlton, Eugene;Buckmelter, Alexandre J.;Ren, Li;Rast, Bryson;Schlacter, Stephen T.;Wenglowsky, Steven Mark US2007/49603, 2007, A1 Location in patent:Page/Page column 66
87-13-8
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27568-04-3
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$6.00/250mg
90-04-0
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27568-04-3
85 suppliers
$6.00/250mg