5-AMINO-1H-BENZOIMIDAZOLE-2-CARBOXYLIC ACID METHYL ESTER synthesis

5synthesis methods

Product Name:5-AMINO-1H-BENZOIMIDAZOLE-2-CARBOXYLIC ACID METHYL ESTER
CAS Number:292070-01-0
Molecular formula:C9H9N3O2
Molecular Weight:191.19

93521-65-4 Synthesis

1H-BenziMidazole-2-carboxylic acid, 5-nitro-, Methyl ester

93521-65-4
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5-AMINO-1H-BENZOIMIDAZOLE-2-CARBOXYLIC ACID METHYL ESTER

292070-01-0
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Yield:292070-01-0 78%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol at 20;

Steps:

2.3 Methyl 5-amino-1H-benzo[d]imidazole-2-carboxylate

Methyl 5-nitro-1H-benzo[d]imidazole-2-carboxylate 2c (1.5g, 6.8mmol) was suspended in 50mL of methanol, 10% palladium/carbon (150mg) was added, the mixture was stirred overnight at room temperature under hydrogen atmosphere.
The mixture was filtered through diatomite, and washed with 5mL of methanol, the filtrate was concentrated under reduced pressure to obtain methyl 5-amino-1H-benzo[d]imidazole-2-carboxylate 2d (1.015g, brown oily liquid), yield: 78%.
MS m / z (ESI): 191.9 [M + 1]

References:

EP3339305,2018,A1 Location in patent:Paragraph 0078; 0081

5805-53-8 Synthesis