ChemicalBook CAS DataBase List (2E)-3-CYCLOHEXYLPROP-2-ENOIC ACID

(2E)-3-CYCLOHEXYLPROP-2-ENOIC ACID synthesis

11synthesis methods

Product Name:(2E)-3-CYCLOHEXYLPROP-2-ENOIC ACID
CAS Number:56453-86-2
Molecular formula:C9H14O2
Molecular Weight:154.21

17343-88-3

56453-86-2

(2E)-3-Cyclohexyl-2-propenoic acid was prepared from ethyl (E)-3-cyclohexyl-2-propenoate by a hydrolysis reaction. The procedure was as follows: ethyl (E)-3-cyclohexylpropenoate was hydrolyzed under standard conditions to give trans-3-cyclohexylacrylic acid in 78% yield. The product was colorless needle-like crystals with a melting point of 46-47 °C (hexane recrystallization). Analyzed by 1H NMR (CDCl3, 400 MHz), the chemical shifts δ: 1.09-1.38 (m, 5H, cyclohexyl-H), 1.63-1.85 (m, 5H, cyclohexyl-H), 2.18 (m, 1H, cyclohexyl-H), 5.78 (d, J = 16.0 Hz, 1H, =CH-CO2-), 7.01 (dd, J = 6.8 Hz, 16.0 Hz, 1H, cyclohexyl-CH=). 13C NMR (CDCl3, 100 MHz) analysis showed chemical shifts δ: 25.7 (t, cyclohexyl), 25.9 (t, cyclohexyl), 31.6 (t, cyclohexyl), 40.5 (d, cyclohexyl), 118.0 (d, =CH-CO2-), 157.1 (d, cyclohexyl-CH=), 171.3 (s, C=O). IR spectra (KBr) showed the characteristic absorption peak at 1686 cm-1. Mass spectrometry results: EI-MS m/z 154 (M+); FAB-MS m/z 154 (M+); HR FAB-MS m/z 154.0995 (M+, calculated value of C9H14O2 154.0994) . Elemental analysis results: calculated values for C9H14O2: C, 70.10; H, 9.15. measured values: C, 70.01; H, 9.18. All spectral data are in agreement with literature reports (Alhamadsheh et al., 2007).

141-82-2 Synthesis

141-82-2
782 suppliers
$5.00/25g

2043-61-0 Synthesis

2043-61-0
340 suppliers
$6.00/5g

56453-86-2
65 suppliers
$39.00/100mg

Yield:56453-86-2 99%

Reaction Conditions:

with piperidine;pyridine for 2 h;Heating;Inert atmosphere;Schlenk technique;

References:

Hartley, Will C.;Schiel, Florian;Ermini, Elena;Melchiorre, Paolo [Angewandte Chemie - International Edition,2022,vol. 61,# 26,art. no. E202204735][Angew. Chem.,2022,vol. 134,# 26] Location in patent:supporting information

17343-88-3
24 suppliers
inquiry

56453-86-2
65 suppliers
$39.00/100mg

References