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ChemicalBook CAS DataBase List (2S,3S)-3-METHYLPYRROLIDINE-2-CARBOXYLIC ACID

(2S,3S)-3-METHYLPYRROLIDINE-2-CARBOXYLIC ACID synthesis

9synthesis methods
-

Yield:10512-89-7 90%

Reaction Conditions:

Stage #1: methyl (2S,3S)-N-tert-butoxycarbonyl-3-methylprolinatewith hydrogenchloride in water; for 3 h;Reflux;
Stage #2: with ammonium hydroxide;dowex 50Wx8 in water;

References:

Oba, Makoto;Saegusa, Tsuneki;Nishiyama, Naohiro;Nishiyama, Kozaburo [Tetrahedron,2009,vol. 65,# 1,p. 128 - 133] Location in patent:experimental part

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