3-(1,3,4-OXADIAZOL-2-YL)PHENOL synthesis
- Product Name:3-(1,3,4-OXADIAZOL-2-YL)PHENOL
- CAS Number:5378-29-0
- Molecular formula:C8H6N2O2
- Molecular Weight:162.15
5818-06-4
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$23.84/1g
149-73-5
548 suppliers
$12.00/5g
5378-29-0
29 suppliers
$45.00/50mg
Yield:5378-29-0 92%
Reaction Conditions:
for 24 h;Reflux;
Steps:
3 Synthesis of 2- (3-hydroxyphenyl) -1,3,4-oxadiazole
A mixture of methyl 3-hydroxybenzoate (6.85 g, 45.0 mmol), hydrazine hydrate (11.2 mL of 80% aqueous solution) and ethanol (60 mL) was heated under reflux for 48 hours and then cooled to room temperature. Washed with cold water and dried to give the target product 3-hydroxybenzohydrazide 4.34g, yield 63%. The resulting 3-hydroxybenzohydrazide (4.34 g, 28.5 mmol) was then mixed with trimethoxymethane (19.7 mL) and heated to reflux for 24 hours. After cooling and removal of excess trimethoxymethane under reduced pressure, the crude product was isolated and purified by silica gel column chromatography to give 4.24 g of the target product in a yield of 92%.
References:
CN107266505,2017,A Location in patent:Paragraph 0048; 0050
122-51-0
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5818-06-4
90 suppliers
$23.84/1g
5378-29-0
29 suppliers
$45.00/50mg
19438-10-9
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$6.00/5g
5378-29-0
29 suppliers
$45.00/50mg
79678-37-8
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$148.00/5g
5378-29-0
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$45.00/50mg
99-06-9
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$5.00/25g
5378-29-0
29 suppliers
$45.00/50mg