3-(1-methyl-1,2,3,6-tetrahydropyrid-4-yl)indole synthesis
- Product Name:3-(1-methyl-1,2,3,6-tetrahydropyrid-4-yl)indole
- CAS Number:17403-03-1
- Molecular formula:C14H16N2
- Molecular Weight:212.29
Yield:17403-03-1 80%
Reaction Conditions:
with potassium hydroxide in methanol; for 18 h;Reflux;
Steps:
11.1
11. 6-(3-Fluoro-4-methoxybenzyl)-3-methyl-2,3,4,7-tetrahydro-1 H-indolo[2,3- c][1 ,7]naphthyridine dihydrochlorideStep 1 : 3-(1-Methyl-1 ,2,3,6-tetrahydropyridin-4-yl)-1 H-indole.; Indole (15.0 g) is suspended in methanol (250 ml), 1-methylpiperidin-4-one (14.4 g) and potassium hydroxide (14.3 g) are added and the reaction mixture is refluxed for 18 h. After that, the mixture is cooled, the crystalline precipi- tate is filtered, washed with methanol and dried to obtain 21.64 g (80%) of 3-(1-methyl-1 ,2,3,6- tetrahydropyridin-4-yl)-1 H-indole. mp. 227° - 2280C.
References:
WO2010/15588,2010,A1 Location in patent:Page/Page column 105-106
1445-73-4
440 suppliers
$15.00/25g
120-72-9
658 suppliers
$6.00/25g
55556-55-3
0 suppliers
inquiry
17403-03-1
21 suppliers
inquiry
120-72-9
658 suppliers
$6.00/25g
17403-03-1
21 suppliers
inquiry