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ChemicalBook CAS DataBase List 3-(1-METHYL-CYCLOHEXYL)-3-OXO-PROPIONITRILE
95882-32-9

3-(1-METHYL-CYCLOHEXYL)-3-OXO-PROPIONITRILE synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: oxalyl chloride; DMF / CH2Cl2 / 3 h / Heating
2.1: n-BuLi; 2,2'-bipyridine / tetrahydrofuran / -70 - 0 °C
2.2: tetrahydrofuran; CH2Cl2 / -70 - 20 °C

References:

Regan, John;Moss, Neil;Pargellis, Chris;Pav, Sue;Proto, Alfred;Swinamer, Alan;Tong, Liang;Torcellini, Carol;Breitfelder, Steffen;Cirillo, Pier;Gilmore, Thomas;Graham, Anne G.;Hickey, Eugene;Klaus, Bernhard;Madwed, Jeffrey;Moriak, Monica [Journal of Medicinal Chemistry,2002,vol. 45,# 14,p. 2994 - 3008]

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