3-(2-bromophenyl)butan-2-one synthesis

5synthesis methods

Product Name:3-(2-bromophenyl)butan-2-one
CAS Number:21905-99-7
Molecular formula:C10H11BrO
Molecular Weight:227.0977

18698-97-0 Synthesis

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Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: 100 percent / thionyl chloride / 2 h
2.1: CuI / diethyl ether; petroleum ether / 0.08 h / cooling
2.2: 79 percent / diethyl ether; petroleum ether / 0.5 h / -78 °C
3.1: 98 percent / LDA / tetrahydrofuran / 1.5 h / -78 - 20 °C

References:

Viswanathan, Rajesh;Prabhakaran, Erode N.;Plotkin, Michael A.;Johnston, Jeffrey N. [Journal of the American Chemical Society,2003,vol. 125,# 1,p. 163 - 168]

21906-31-0 Synthesis